The Role of Endothelial Dysfunction in Arteriovenous Fistula Maturation
Congressional District Code:
Biomedical Laboratory R&D
October 2016 -
FY 2021 Funding Amount:
Total Award Amount (all years):
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Project Summary/Abstract The vascular access is the “Achilles Heel” of the hemodialysis procedure. Sixty percent of arteriovenous fistulas (AVF) that are created fail to mature successfully for dialysis use (AVF non-maturation), resulting in a very significant clinical morbidity and mortality for hemodialysis patients. On a radiologic level, AVF non- maturation is most commonly characterized by a juxta-anastomotic stenosis, and at a histological level it is characterized by a combination of...