Photo: ©iStock/Varlay(12/17/2025) Eastern Colorado VA researchers found Veterans prescribed semaglutide, a GLP-1 inhibitor, in a VA weight management clinic had an average of 10% weight loss and improvements in body mass index, blood pressure, “bad” cholesterol, triglycerides, and blood sugar after one year. Researchers retrospectively followed 201 Veterans prescribed semaglutide specifically for weight loss rather than for diabetes or other medical conditions, who were also provided nutritional counseling and a weight-loss program that included exercise and physical health practices. In addition to measurable health improvements, the Veterans also reported improvements in their overall quality of life. The findings demonstrate the effectiveness of GLP-1 inhibitors in a VA weight management program, suggesting the medications could be an effective addition to obesity and cardiovascular disease treatments. (Journal of General Internal Medicine, Nov. 13, 2025)
