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(04/29/2026) A study led by VA Connecticut researchers found long-term opioid therapy was linked to higher risk of infection-related dental disease. The study included data on more than two million Veterans, 36% of whom received long-term opioid therapy. Those taking opioid medications for more than 90 days had a 24% higher chance of tooth decay, infections, or tooth loss. The researchers suggest the immune suppression and reduced saliva flow caused by opioids may explain this connection. The findings suggest oral health risks need to be taken into account when prescribing long-term opioid therapy. (PLoS One, Feb. 2, 2026)