Office of Research & Development

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Point of Care Research (POC-R)


Point of Care Research (POC-R) is a new approach to clinical study design that embeds trials into regular medical care. It is uniquely positioned to compare two or more approved treatments or diagnostic techniques that are considered to be equivalent.

These trials take advantage of the Electronic Health Record (EHR) to facilitate participant recruitment and data collection, minimizing study overhead and streamlining the experience for patients.

Starting a Point of Care Research Study

Eligible VA investigators who wish to start a POC-R study must submit a Letter of Intent (LOI) to the program office. This document serves as a request for planning, and includes:

  • Study objectives
  • Importance of the research to VA and its patients
  • Feasibility of conducting the research as a POC-R study
  • Summary of preliminary research and data to support further investigation

Please refer to the POC-R LOI Submission Guidelines (202 KB, PDF) for specific instructions.


A point-of-care clinical trial comparing insulin administered using a slid-ing scale versus a weight-based regimen. Fiore LD, Brophy M, Ferguson RE, D'Avolio L, Hermos JA, Lew RA, Doros G, Conrad CH, O'Neil JA Jr, Sabin TP, Kaufman J, Swartz SL, Lawler E, Liang MH, Gaziano JM, Lavori PW. Clin Trials. 2011 Apr;8(2):183-95.

Implementation of the Department of Veterans Affairs' first point-of-care clinical trial . D'Avolio L, Ferguson R, Goryachev S, Woods P, Sabin T, O'Neil J, Conrad C, Gillon J, Escalera J, Brophy M, Lavori P, Fiore L. J Am Med Inform Assoc. 2012 Feb 24.

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Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.