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CSP No. 563, Prazosin and Combat Trauma PTSD (PACT) Study

Posttraumatic stress disorder (PTSD) is a debilitating and disabling mental disorder that afflicts at least 25% of Veterans who have suffered life-threatening war zone trauma. Trauma-related nightmares and sleep disturbance are among the most treatment-resistant PTSD symptoms in Veterans. Placebo-controlled pilot studies demonstrate that the generically available CNS-active alpha-1 adrenoreceptor antagonist prazosin substantially reduces PTSD trauma nightmares and sleep disturbance and improves global clinical status (sense of well being and ability to function) in Veterans.

The VA CSP No. 563 PACT Study is investigating to see if taking prazosin can help reduce nightmares and other sleep problems in people who have PTSD. This 26 week randomized double-blind placebo-controlled study is designed to demonstrate both short term efficacy and long term effectiveness of prazosin for PTSD.

Three hundred twenty-six Veterans with war zone -related PTSD and persistent trauma nightmares will be randomized 1:1 to prazosin or placebo. During the first 10 weeks of the study, participants will be randomized to prazosin or placebo. During the remaining 16 weeks of the 26 week trial, subjects will continue to receive stable-dose double-blind prazosin or placebo, but will have the option to receive additional psychotropic medications and/or psychotherapeutic interventions, as needed.

This study is carried out at 13 VA Medical Centers around the country. The study is taking place at the following locations:


  • VA Medical Center, Long Beach



  • Atlanta VA Medical and Rehab Center, Decatur


  • VA Medical Center, Kansas City MO
    Kansas City, Missouri, United States, 64128

New Mexico

  • New Mexico VA Health Care System, Albuquerque

New York

North Carolina

Salisbury VAMC

  • Salisbury, North Carolina, United States, 28144

Rhode Island

  • VA Medical Center, Providence

South Carolina


  • VA Salt Lake City Health Care System, Salt Lake City


  • Wlliam S. Middleton Memorial Veterans Hospital, Madison

For more information on CSP No. 563 PACT Study, please contact:

National Study Coordinator: Hollie Holmes,
Project Manager: Beverly Ventura,

Principal Investigators:
VA Puget Sound Health Care System, Seattle
Study Co-Chair: Murray Raskind, MD,
Study Co-Chair: Elaine Peskind, MD,
Study Related Link:

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Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.