CSP No. 563, Prazosin and Combat Trauma PTSD (PACT) Study
Posttraumatic stress disorder (PTSD) is a debilitating and disabling mental disorder that afflicts at least 25% of Veterans who have suffered life-threatening war zone trauma. Trauma-related nightmares and sleep disturbance are among the most treatment-resistant PTSD symptoms in Veterans. Placebo-controlled pilot studies demonstrate that the generically available CNS-active alpha-1 adrenoreceptor antagonist prazosin substantially reduces PTSD trauma nightmares and sleep disturbance and improves global clinical status (sense of well being and ability to function) in Veterans.
The VA CSP No. 563 PACT Study is investigating to see if taking prazosin can help reduce nightmares and other sleep problems in people who have PTSD. This 26 week randomized double-blind placebo-controlled study is designed to demonstrate both short term efficacy and long term effectiveness of prazosin for PTSD.
Three hundred twenty-six Veterans with war zone -related PTSD and persistent trauma nightmares will be randomized 1:1 to prazosin or placebo. During the first 10 weeks of the study, participants will be randomized to prazosin or placebo. During the remaining 16 weeks of the 26 week trial, subjects will continue to receive stable-dose double-blind prazosin or placebo, but will have the option to receive additional psychotropic medications and/or psychotherapeutic interventions, as needed.
This study is carried out at 13 VA Medical Centers around the country. The study is taking place at the following locations:
- VA Medical Center, Loma Linda
- VA Medical Center, Long Beach
- Atlanta VA Medical and Rehab Center, Decatur
- VA Medical Center, Kansas City MO
Kansas City, Missouri, United States, 64128
- New Mexico VA Health Care System, Albuquerque
- VA Medical Center, Durham
- Salisbury, North Carolina, United States, 28144
- VA Medical Center, Providence
- WJB Dorn Veterans Hospital, Columbia
- VA Salt Lake City Health Care System, Salt Lake City
- Wlliam S. Middleton Memorial Veterans Hospital, Madison
For more information on CSP No. 563 PACT Study, please contact:
National Study Coordinator: Hollie Holmes, Hollie.Holmes@va.gov
Project Manager: Beverly Ventura, Beverly.Ventura@va.gov
VA Puget Sound Health Care System, Seattle
Study Co-Chair: Murray Raskind, MD, Murray.Raskind@va.gov
Study Co-Chair: Elaine Peskind, MD, Elaine.Peskind@va.gov
Study Related Link: