Circadian rhythms and cell survival in lithium responsive bipolar disorder.
Michael J McCarthy
San Diego, CA
Congressional District Code:
Biomedical Laboratory R&D
April 2017 -
FY 2021 Funding Amount:
Total Award Amount (all years):
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Bipolar disorder (BD) is a common mental illness that affects 1‐2% of the world's population, including >100,000 veterans, causing severe mood symptoms, volumetric of loss of brain gray matter, and elevated rates of suicide. Among its symptoms, BD is associated with disrupted daily 24 hr rhythms (circadian rhythms) in sleep and activity. However, due to similarities and overlap with other psychiatric syndromes, it is commonly misdiagnosed and treatment delays are frequent. Lithium is an exce...