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VA COVID-19 Observational Research Collaboratory (CORC)

VA COVID-19 Observational Research Collaboratory (CORC)


To improve Veteran’s health by conducting and supporting rigorous research to understand the long-term effects of SARS-CoV-2 infection while fostering research collaborations within and outside of the Department of Veterans Affairs.


Coordinating Center (CC)

The 3 pillars of the CC are a Data Core, Methods Core, and Partnerships Core, which will work together to carry out the following aims:

  • CC-Aim 1: Develop a data infrastructure to support dynamic analytic datasets of SARS-CoV-2 infected and uninfected comparator cohorts that will facilitate research on a broad range of VHA health record-based outcomes
  • CC-Aim 2: Generate and disseminate documentation of matched comparators, exposures, outcomes, and covariates
  • CC-Aim 3: Provide methodologic guidance and support to VA investigators and operational partners
  • CC-Aim 4: Understand the medical and non-medical effects of SARS-CoV-2 by comparing clinical, economic, and patient- reported outcomes between SARS-CoV-2 infected and uninfected VHA patients
  • CC-Aim 5: Describe incidence and predictors of key long-term adverse outcomes and manifestations of SARS-CoV-2 infection

Long-Term Outcome Study (LTO)

The LTO will be responsible for carrying out a rigorous mixed methods study of the long-term effects of SARS-CoV-2 infection on Veterans, with support from the CC. By triangulating a range of data sources, the LTO will:

  • LTO-Aim 1: Compare VHA patients infected and uninfected with SARS-CoV-2 on outcomes that can be measured in electronic health records and claims datasets, such as mortality, hospital readmissions, new and exacerbated conditions, and new mental health conditions
  • LTO-Aim 2: Compare VHA patients infected and uninfected by SARS-CoV-2 on veteran-reported outcomes, including as self-reported symptoms, disability, informal caregiving receipt, and financial impacts
  • LTO-Aim 3: Elicit Veteran experiences of recovery after SARS-CoV-2 infection through semi-structured interviews
  • LTO-Aim 4: Estimate current and future health system needs to address long-term effects of SARS-CoV-2

For more information on VA research projects related to COVID-19:

Participating in Research

Anyone over the age of 18, including Veterans, their friends and family of Veterans, and VA staff can participate in VA national COVID-19 research efforts by registering at

Collaborating VA Medical Centers


Additional Locations

  1. Palo Alto VA HSRD Center for Innovation to Implementation (Ci2i): Thomas Osborne
  2. West Haven VA Clinical Epidemiology Research Center (CERC). Mihaela Aslan

Data Resources/Collaborators

  • MVP
  • EPIC3
  • VIReC
  • HSR&D Collaborative Merits

  • CORC provides support to the HSR&D/CSR&D Collaborative Merits. We are proud to partner with these projects to improve care of Veterans with Long-COVID:

    1. Leverage Knowledge of Chronic Multisymptom Illness to Improve Care for Veterans | Principal Investigators: Drs. Lisa McAndrew and Shannon Nugent
    2. Covid Post-Exposure Evaluation and Symptomatology (COPES) Center: Identifying Post-COVID Phenotypes and Related Health Inequities | Principal Investigators: Drs. April Mohanty and Sara Knight
    3. Covid Post-Exposure Evaluation and Symptomatology (COPES) Center | Principal Investigators: Drs. Matthew Samore, Mary Jo Pugh, and Adam Gordon
    4. Genetic predictors, pathophysiological mechanisms, and functional consequences of post-acute sequelae of SARS-CoV-2: Exercise challenge of gut microbiome and neuroinflammation in PASC | Principal Investigators: Drs. Dane Cook and Jacob Lindheimer


The CORC is supported by the Department of Veterans Affairs. Primary funding comes from:

Additional support comes from the following sources:

  • C19 20-208 (Hynes)
  • CSR&D grant COVID19-8900-11 (Ioannou)
  • CSR&D grant COVID19-8990-19 (Boyko)
  • RCS 21-136 (Hynes)
  • RCS 10-391 (Maciejewski)
  • CIN 13-410 (Maciejewski)
  • CSP#2038 COPE-VA - COVID-19 Pharmacotherapy Effectiveness (Co-Chairs: Bajema and Ioannou; CERC Director: Mihaela Aslan)


For any questions about CORC and our website, please contact Natalya Wawrin at

Questions about the R&D website? Email the Web Team

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.