Funded Project Details - FY2021
|Title:|| Modulation of Steroid Suppression by Alveolar Macrophage Efferocytosis|
Jeffrey L. Curtis
||Ann Arbor, MI
|Congressional District Code:
||Clinical Science R&D
|| October 2015 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Treating chronic obstructive pulmonary disease (COPD) patients with inhaled glucocorticosteroids has been convincingly shown to increase their risk of pneumonia, but the responsible mechanisms are undefined. Work from this laboratory suggests a possible mechanism, related to the increased numbers of cells dying by apoptosis in the lungs in COPD, especially in emphysema. Uptake of apoptotic cells (“efferocytosis”) suppresses the ability of alveolar macrophages (AMØ) to fight infections. By marked...
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