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Project Number: | I01CX000911-01A2 |
| Title: | Modulation of Steroid Suppression by Alveolar Macrophage Efferocytosis |
| Principal Investigator: | Jeffrey L. Curtis |
| Location: | Ann Arbor, MI |
| Congressional District Code: | 12 |
| Research Service: | Clinical Science R&D |
| Project Period: | October 2015 - March 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$694,903 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Treating chronic obstructive pulmonary disease (COPD) patients with inhaled glucocorticosteroids has been convincingly shown to increase their risk of pneumonia, but the responsible mechanisms are undefined. Work from this laboratory suggests a possible mechanism, related to the increased numbers of cells dying by apoptosis in the lungs in COPD, especially in emphysema. Uptake of apoptotic cells (“efferocytosis”) suppresses the ability of alveolar macrophages (AMØ) to fight infections. By marked... |