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Funded Project Details - FY2021

Project Number:

Title: Distinct MHCII APC Requirements for T Cell and B Cell Effector Functions
Principal Investigator:

Terri M Laufer

Location: Philadelphia, PA
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: October 2015 - September 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The success of the adaptive immune system depends upon the rapid generation of effector cells and the maintenance of memory to the antigens and pathogens previously encountered. The germinal center (GC) is the site of somatic hypermutation of antibodies, antibody class switching to IgG, and a central source of memory B cells and thus is critical for effective humoral immunity. The formation of GCs within secondary lymphoid organs after challenge with protein immunizations or viral infections is...

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