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Project Number: | I01BX002322-01A2 |
| Title: | NCC and ENaC form a Sodium Transporting Complex |
| Principal Investigator: | Robert Hoover |
| Location: | Decatur, GA |
| Congressional District Code: | 5 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2015 - June 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$695,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The sodium chloride co-transporter (NCC) and the epithelial sodium channel (ENaC) are two key sodium transporting proteins in the distal tubule of the mammalian kidney. Hyperactivity of either protein results in hypertension and hypoactivity results in hypotension. These two proteins are co-expressed in the second part of the distal convoluted tubule (DCT2) and are regulated by many of the same proteins. However, associations between the two have not been investigated. Preliminary data indicates... |