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Project Number: | I01BX001164-05 |
| Title: | CARP-1: A Potential Therapeutic Agent for Breast Cancer |
| Principal Investigator: | Arun Rishi |
| Location: | Allen Park, MI |
| Congressional District Code: | 13 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2016 - December 2020 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$999,968 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Despite recent advances in clinical management, the molecular complexity of triple-negative breast cancers (TNBC) and therapy-associated side effects often limit effectiveness of many therapies. Development of new and improved strategies for TNBC treatment remains urgent. We previously discovered an apoptosis regulatory protein CARP-1/CCAR1. CARP-1 functions to transduce cell growth as well as chemotherapy (adriamycin, etoposide, or Iressa)-dependent inhibitory signaling. CARP-1 expression corre... |