Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government
ORD only    All VA Research websites

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021

Project Number:

Title: Macrophage-mediated gene delivery of neurotrophic factors for Parkinson's disease
Principal Investigator:

Senlin Li

Location: San Antonio, TX
Congressional District Code: 21
Research Service: Biomedical Laboratory R&D
Project Period: January 2016 - December 2020
FY 2021 Funding Amount: $36,577
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The development of a neuroprotective/restorative therapy for Parkinson's disease (PD) would be a major therapeutic advance, particularly for our veterans. Glial cell line-derived neurotrophic factor (GDNF) has been the most potent trophic molecule to dopamine neurons affected in PD. GDNF requires focal delivery as it does not cross the blood-brain barrier (BBB). However, clinical trials of GDNF in PD patients have given mixed results. It is challenging to achieve therapeutic levels of GDNF for a...

Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.