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Funded Project Details - FY2021




Project Number:

I01BX001060-05A1
Title: Pathogenesis and Impact of Islet Amyloid
Principal Investigator:

Steven E. Kahn

Location: Seattle, WA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2016 - December 2020
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
$773,550
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

 DESCRIPTION (provided by applicant): ABSTRACT Islet amyloid formation is a pathological hallmark of type 2 diabetes and is observed in >90% of patients with the disease. These amyloid deposits are associated with ß-cell apoptosis resulting in ß-cell mass loss. In the autoimmune disease process of type 1 diabetes, cytokines are responsible for the induction of ß-cell apoptosis. Studies of the mechanisms of ß-cell loss have identified the involvement of a number of pro- apoptotic mole...



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