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Project Number: | I01BX001060-05A1 |
| Title: | Pathogenesis and Impact of Islet Amyloid |
| Principal Investigator: | Steven E. Kahn |
| Location: | Seattle, WA |
| Congressional District Code: | 7 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2016 - December 2020 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$773,550 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): ABSTRACT Islet amyloid formation is a pathological hallmark of type 2 diabetes and is observed in >90% of patients with the disease. These amyloid deposits are associated with ß-cell apoptosis resulting in ß-cell mass loss. In the autoimmune disease process of type 1 diabetes, cytokines are responsible for the induction of ß-cell apoptosis. Studies of the mechanisms of ß-cell loss have identified the involvement of a number of pro- apoptotic mole... |