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Funded Project Details - FY2021

Project Number:

Title: Regulation of Renal BK Channel by WNK Kinase and its Interacting Proteins
Principal Investigator:

Hui Cai

Location: Decatur, GA
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: April 2016 - March 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


 DESCRIPTION (provided by applicant): Project Summary WNK kinases are a family of serine/threonine kinases (1). Mutations of WNK1 and WNK4 kinases result in pseudohypoaldosteronism type II (PHA II), featuring hypertension, hyperkalemia and metabolic acidosis (4). WNK kinases play an important role in maintaining electrolyte homeostasis (5). WNKs not only modulate sodium chloride cotransporter (NCC) (6), sodium potassium chloride cotransporter (NKCC) (7; 8), potassium chloride cotransp...

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