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Funded Project Details - FY2021

Project Number:

Title: Amyloidopathy, cholinopathy, dopamine responsiveness and freezing of gait in PD
Principal Investigator:

Nicolaas I Bohnen

Location: Ann Arbor, MI
Congressional District Code: 12
Research Service: Rehabilitation R&D
Project Period: July 2016 - December 2020
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


 DESCRIPTION (provided by applicant): Early stage Parkinson disease (PD) is characterized by a 'honeymoon' phase in terms of responsiveness of motor symptoms, including gait, to dopaminergic pharmacotherapy. Advancing PD is associated with disabling axial motor complications, such as freezing of gait (FoG), with decreased or even refractory dopamine responsiveness in over 50% of patients. The management of dopamine resistant gait problems represents the most important unmet need in PD. At...

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