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Project Number: | I01BX000900-05A2 |
| Title: | PLTP as a target for lowering VLDL production |
| Principal Investigator: | Xian-Cheng Jiang |
| Location: | Brooklyn, NY |
| Congressional District Code: | 4 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2016 - December 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$750,870 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): Summary Hypercholesterinemia-mediated cardiovascular diseases can be treated by statins. However, there are many instances of unresponsiveness and intolerance. Thus, there is urgent need for new approaches to lower plasma LDL, preferably that act synergistically with statins. Blocking liver VLDL, the precursor of LDL, secretion has long been recognized as an effective alternative to lower LDL in the circulation. However, this can have unwanted con... |