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Funded Project Details - FY2021

Project Number:

Title: PLTP as a target for lowering VLDL production
Principal Investigator:

Xian-Cheng Jiang

Location: Brooklyn, NY
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: July 2016 - December 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


 DESCRIPTION (provided by applicant): Summary Hypercholesterinemia-mediated cardiovascular diseases can be treated by statins. However, there are many instances of unresponsiveness and intolerance. Thus, there is urgent need for new approaches to lower plasma LDL, preferably that act synergistically with statins. Blocking liver VLDL, the precursor of LDL, secretion has long been recognized as an effective alternative to lower LDL in the circulation. However, this can have unwanted con...

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