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Funded Project Details - FY2021




Project Number:

I01BX002880-01A2
Title: Mechanisms of Chronic Intermittent Hypoxia Induced Airflow Obstruction during Allergic Lower Airway Inflammation
Principal Investigator:

Mihaela Teodorescu

Location: Madison, WI
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: April 2016 - September 2021
FY 2021 Funding Amount: $17,072
Total Award Amount
(all years):
$720,431
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

 DESCRIPTION (provided by applicant): The Gap in Knowledge/ Work Accomplished: Obstructive sleep apnea (OSA) is highly common among patients with asthma and exacerbates the airways disease, but mechanisms are unknown. Chronic intermittent hypoxia (CIH), a hallmark feature of OSA, may be one important contributor. In our recently published and preliminary work, CIH exposure during allergen-induced airway inflammation in rats: 1) caused airflow limitation; 2) increased peribronchial col...



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