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Funded Project Details - FY2021




Project Number:

I01BX003385-01
Title: Therapeutic Development in Segmental Demyelination
Principal Investigator:

Jun Li

Location: Allen Park, MI
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: April 2016 - September 2021
FY 2021 Funding Amount: $30,000
Total Award Amount
(all years):
$652,500
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

 DESCRIPTION (provided by applicant): Demyelination shunts depolarizing current out of the nerve. As a result, nerve conduction of action potentials can be slowed or even eliminated. The later is known as conduction block. This change causes neurological disabilities such as sensory loss, vision loss, and limb paralysis in a variety of neurological diseases. We have found that patients and mice with FIG4 deficiency develop a demyelinating neuropathy. This demyelination closely recapi...



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