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Funded Project Details - FY2021

Project Number:

Title: Novel targets to treat head and neck cancer in Veterans
Principal Investigator:

Umamaheswar Duvvuri

Location: Pittsburgh, PA
Congressional District Code: 14
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - September 2021
FY 2021 Funding Amount: $80,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


 DESCRIPTION (provided by applicant): Veterans suffer at a disproportional rate from squamous cell carcinoma of the head and neck (SCCHN) due to carcinogen exposure from tobacco and alcohol. Despite aggressive treatments, SCCHN is a devastating disease that portends an overall 5-year survival of only ~50%. A comprehensive genomic analysis of SCCHN revealed that ~30% of these tumors overexpress a gene that encodes a calcium-activated chloride channel (TMEM16A/ ANO1). Mechanistic studie...

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