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Funded Project Details - FY2021

Project Number:

Title: Mechanisms of Virus-induced Injury in the Brain and Spinal Cord
Principal Investigator:

Kenneth L. Tyler

Location: Denver, CO
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2021
FY 2021 Funding Amount: $37,500
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


 DESCRIPTION (provided by applicant): Treatments for virus-induced diseases of the central nervous system (CNS) are sub-optimal or non- existent. Virus infection of the CNS results in a robust host neuroinflammatory response, defined by the activation of resident CNS immune cells (microglia and astrocytes) and the up-regulation of pro-inflammatory genes. The role of these responses in virus-induced CNS disease remains unclear. Neuroinflammatory responses likely play a protective role...

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