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Project Number: | I01BX003259-01A1 |
| Title: | Cell-free DNA is a driver of non-alcoholic steatohepatitis via TLR9 activation |
| Principal Investigator: | Wajahat Z. Mehal |
| Location: | West Haven, CT |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2016 - September 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$665,925 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): Nonalcoholic steatohepatitis (NASH) is the most common liver disease among veterans and is characterized by hepatic steatosis, sterile inflammation and liver damage [1]. NASH is associated with the metabolic syndrome, and can progress to cirrhosis and cancer. The mechanisms governing NASH development are not known, and currently there is no effective therapy. We have shown that the DNA receptor TLR9 (TOLL like receptor 9) is required for acute sterile in... |