Role of Inflammation and Fibrosis in Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms
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Biomedical Laboratory R&D
October 2016 -
FY 2021 Funding Amount:
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DESCRIPTION (provided by applicant): Acute and chronic inflammation is a common finding in the adult prostate that has been implicated in the genesis of lower urinary tract symptoms (LUTS) in aging men. The strong association has generated considerable interest in prostate inflammation and its potential as a therapeutic target to prevent or treat LUTS. We and others have postulated that prostatic inflammation contributes to development of LUTS in two ways: (1) producing irritative voidin...