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Funded Project Details - FY2021

Project Number:

Title: Regulation of Functional Activity of Osteoclasts
Principal Investigator:

K. H. William Lau

Location: Loma Linda, CA
Congressional District Code: 31
Research Service: Biomedical Laboratory R&D
Project Period: July 2016 - December 2020
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


 DESCRIPTION (provided by applicant): Past work of this group has demonstrated that an osteoclastic protein-tyrosine phosphatase (PTP-oc) is a positive activator of the osteoclast activity. Recent preliminary studies have disclosed four exciting discoveries relevant to the mechanism of how PTP-oc expression in osteoclasts is regulated: First, PTP-oc expression is controlled primarily by post-transcriptional mechanisms. Second, the post-transcriptional regulation of PTP-oc expression in o...

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