Endothelial topography, phosphatidylserine, and procoagulant activity
Congressional District Code:
Biomedical Laboratory R&D
October 2016 -
FY 2021 Funding Amount:
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DESCRIPTION (provided by applicant): Blood coagulation prevents hemorrhage and also contributes to thrombotic diseases including myocardial infarction, stroke, and venous thromboembolism. A great deal has been learned about blood coagulation on the scale of a test tube, an artery, and a vein. However, the regulation of blood coagulation at the single cell level has been largely unexplored. Under ordinary conditions endothelial cells that line all arteries and veins have anticoagulant...