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Project Number: | I01BX001234-05A1 |
| Title: | Biology of IGFs in Bone |
| Principal Investigator: | Thomas L. Clemens |
| Location: | Baltimore, MD |
| Congressional District Code: | 7 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2016 - June 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$696,250 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): The long-term goals of this Merit project are focused on characterizing the mechanisms, which distinguish the actions of insulin and IGF-1 in skeletal cells. During the last funding period we identified a novel endocrine loop through which insulin stimulates the production of osteocalcin by osteoblasts, which in turn, functions as a hormone to increase pancreatic insulin production and enhance insulin sensitivity in peripheral tissues. Additional stu... |