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Project Number: | I01BX001396-05 |
| Title: | Prolyl Hydroxylases, Epigenetics and Osteoarthritis |
| Principal Investigator: | Subburaman Mohan |
| Location: | Loma Linda, CA |
| Congressional District Code: | 31 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2016 - September 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$753,412 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): Project Summary/Abstract The long-term goals of this Merit project are focused on characterizing the roles and mechanisms of actions of vitamin C in skeletal biology since its deficiency induces skeletal fractures. During the last funding period, we identified novel roles fo prolyl hydroxylase domain proteins (PHDs) in regulating articular cartilage (AC) development besides mediating vitamin C effects on osteoblasts (OBs). By using mice with a conditi... |