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Funded Project Details - FY2021

Project Number:

Title: Targeting Tau for TBI
Principal Investigator:

David Kang

Location: Tampa, FL
Congressional District Code: 14
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - March 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


 DESCRIPTION (provided by applicant): Here, we will determine if improved small molecules can protect the microtubule associated protein tau from a pathogenic cascade caused by the molecular chaperone Hsc70. Tau accumulates in traumatic brain injury (TBI), leading to neurodegeneration and cognitive deficits. Active Hsc70 binds to tau just after microtubule disruption precipitated by bast-­induced axonal injury and then directs tau along one of two paths: I...

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