Funded Project Details - FY2021
|Title:|| HIV reactivation from latency - role of CD4 T cell maturation phenotype|
||San Diego, CA
|Congressional District Code:
||Biomedical Laboratory R&D
|| July 2016 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
DESCRIPTION (provided by applicant): The "shock and kill" treatment strategy has been envisioned as a controlled induction of virus reactivation in the presence of combination antiretroviral therapy (cART) to reveal latently infected cells for immune system recognition and destruction. Histone deacetylase inhibitors (HDACis) have potential for HIV reactivation in patients; however, further optimization of these strategies is needed to effectively reduce the size of latent reservoir....
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