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Funded Project Details - FY2021




Project Number:

IK2CX001269-01A1
Title: Functional impact of HDL transport of microRNA in rheumatoid arthritis
Principal Investigator:

Michelle Ormseth

Location: Nashville, TN
Congressional District Code: 5
Research Service: Clinical Science R&D
Project Period: January 2017 - December 2021
FY 2021 Funding Amount: $280,462
Total Award Amount
(all years):
$1,395,361
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

 DESCRIPTION (provided by applicant): Recently, high-density lipoproteins (HDL) were discovered to transport microRNAs to cells, leading to altered gene expression. HDL-miRNA cargo and its delivery to target cells can be altered by different disease states and may be responsible for some disease sequelae. A common disease sequela of rheumatoid arthritis (RA) is cardiovascular (CV) disease, which is increased two-fold, but underlying mechanisms are unclear. A potential mechanism is deliver...



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