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Project Number: | IK2CX001269-01A1 |
| Title: | Functional impact of HDL transport of microRNA in rheumatoid arthritis |
| Principal Investigator: | Michelle Ormseth |
| Location: | Nashville, TN |
| Congressional District Code: | 5 |
| Research Service: | Clinical Science R&D |
| Project Period: | January 2017 - December 2021 |
| FY 2021 Funding Amount: | $280,462 |
| Total Award Amount (all years): |
$1,395,361 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): Recently, high-density lipoproteins (HDL) were discovered to transport microRNAs to cells, leading to altered gene expression. HDL-miRNA cargo and its delivery to target cells can be altered by different disease states and may be responsible for some disease sequelae. A common disease sequela of rheumatoid arthritis (RA) is cardiovascular (CV) disease, which is increased two-fold, but underlying mechanisms are unclear. A potential mechanism is deliver... |