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Funded Project Details - FY2021




Project Number:

I01RX002090-01A1
Title: Neurorestorative Therapy for Stroke Injury
Principal Investigator:

Inderjit Singh

Location: Charleston, SC
Congressional District Code: 6
Research Service: Rehabilitation R&D
Project Period: July 2016 - December 2020
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
$1,100,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Aging is the major non-modifiable stroke risk factor in humans, and ischemic stroke is highly prevalent in aged Veterans and other Americans, with an economic burden exceeding $70 billion/year. Furthermore, the rate and the degree of functional recovery in aged stroke patients, as in aged animal models of stroke, are slower than in the young. In the aged brain, excitotoxicity-induced sustained neuronal peroxynitrite production is more prominent, causing sustained calpain activation and thus neur...



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