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Project Number: | I01RX002090-01A1 |
| Title: | Neurorestorative Therapy for Stroke Injury |
| Principal Investigator: | Inderjit Singh |
| Location: | Charleston, SC |
| Congressional District Code: | 6 |
| Research Service: | Rehabilitation R&D |
| Project Period: | July 2016 - December 2020 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$1,100,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Aging is the major non-modifiable stroke risk factor in humans, and ischemic stroke is highly prevalent in aged Veterans and other Americans, with an economic burden exceeding $70 billion/year. Furthermore, the rate and the degree of functional recovery in aged stroke patients, as in aged animal models of stroke, are slower than in the young. In the aged brain, excitotoxicity-induced sustained neuronal peroxynitrite production is more prominent, causing sustained calpain activation and thus neur... |