Funded Project Details - FY2021
|Title:|| Targeting MNK Pathways in Pancreatic Cancer|
Hidayatullah G. Munshi
|Congressional District Code:
||Biomedical Laboratory R&D
|| April 2017 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
The dismal mortality rate for pancreatic ductal adenocarcinoma (PDAC) is attributed to the fact that it is a highly chemo-resistant and aggressive cancer. Current therapies have also not been able to eradicate cancer stem cells (CSCs), which can reestablish tumors following treatment. Notably, PDAC tumors are associated with intensely collagen-rich stroma that we have shown can mediate epithelial-mesenchymal transition (EMT) and contribute to cancer cell invasion. PDAC tumors are also associated...
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