Funded Project Details - FY2021
|Title:|| TRAF3 as a key regulator of B cell survival pathways|
Gail A. Bishop
||Iowa City, IA
|Congressional District Code:
||Biomedical Laboratory R&D
|| October 2016 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Homeostatic survival of B lymphocytes is carefully regulated, and disruption of this regulation is an important factor in pathogenesis of various autoimmune diseases and B cell malignancies. The latter are the most common hematologic cancers in the US population as well as in Veterans, in whom age/gender status, as well as exposures related to their service, can increase risk of B cell cancers. The signaling adapter protein TRAF3 plays an important, B-cell-specific role in restraining homeostati...
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