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Funded Project Details - FY2021

Project Number:

Title: AMP Kinase Activation in Calcineurin Inhibitor Nephrotoxicity
Principal Investigator:

Roslyn B Mannon

Location: Omaha, NE
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - September 2021
FY 2021 Funding Amount: $75,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Solid organ transplantation necessitates the use of lifelong immunosuppression. In particular, the calcineurin inhibitors (CNIs) are utilized in nearly all transplant recipients as they are potent immunosuppressants. In kidney transplantation, the use of CNIs has led to the very low rejection rates of ~7-10% per year. However, long term graft survival has not improved substantially with their utilization, with a mean half-life of 10 years for kidney transplants. A key contributor to late graft i...

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