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Project Number: | I01BX003171-01A2 |
| Title: | Programming Durable Immune Responses in Lung Cancer |
| Principal Investigator: | Shervendra Sharma |
| Location: | West Los Angeles, CA |
| Congressional District Code: | 30 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2016 - March 2021 |
| FY 2021 Funding Amount: | $189,589 |
| Total Award Amount (all years): |
$1,547,926 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: We propose to evaluate the cellular and molecular mechanisms of immune responses following stimulation with therapeutic vaccination and immune checkpoint blockade to establish effective immune responses in lung cancer. We will target the programmed cell death protein 1 (PD-1) pathway that has shown benefit in patients with lung cancer. Patients do not benefit from PD-1 blockade therapy if they lack lymphocytic infiltration of the tumors. We have a novel means to cause tumor T cell infiltration w... |