Funded Project Details - FY2021
|Title:|| Programming Durable Immune Responses in Lung Cancer|
||West Los Angeles, CA
|Congressional District Code:
||Biomedical Laboratory R&D
|| October 2016 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
We propose to evaluate the cellular and molecular mechanisms of immune responses following stimulation with therapeutic vaccination and immune checkpoint blockade to establish effective immune responses in lung cancer. We will target the programmed cell death protein 1 (PD-1) pathway that has shown benefit in patients with lung cancer. Patients do not benefit from PD-1 blockade therapy if they lack lymphocytic infiltration of the tumors. We have a novel means to cause tumor T cell infiltration w...
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