Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government
ORD only    All VA Research websites

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021

Project Number:

Title: Pathophysiology of Extracellular Matrix and Desmin Breakdown in Volume Overload Heart
Principal Investigator:

Louis J. Dellitalia

Location: Birmingham, AL
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - August 2021
FY 2021 Funding Amount: $71,250
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The importance of the extracellular matrix loss in adverse LV remodeling is well established in the isolated pure volume overload of mitral regurgitation. Here the Principal Investigator reports a newly described breakdown of cardiomyocyte cytoskeletal protein desmin that adds an important intracellular structural defect with a direct impact on cardiomyocyte contractile function. This extracellular and intracellular protein breakdown mandates a novel medical therapy that enhances fibroblast extr...

Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.