Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021




Project Number:

I01BX000764-05
Title: Regulation of Calcium Signaling in Retinal Ganglion Cells after Nerve Injury
Principal Investigator:

Nicholas Brecha

Location: West Los Angeles, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2020
FY 2021 Funding Amount: $41,250
Total Award Amount
(all years):
$695,999
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Abstract Severe reductions of vision and blindness due to ocular disease and trauma are major clinical problems that have serious consequences on the Veteran's quality of life. Optic neuropathies from injury to the retina and optic nerve are characterized by a loss of ganglion cells and their axons. Ganglion cell death is initiated by excessive intracellular Ca2+ levels followed by a cascade of deleterious cellular processes that result in apoptosis. Consistent with this observation is the enhan...



Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.