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Funded Project Details - FY2021

Project Number:

Title: Regulation of Calcium Signaling in Retinal Ganglion Cells after Nerve Injury
Principal Investigator:

Nicholas Brecha

Location: West Los Angeles, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2020
FY 2021 Funding Amount: $41,250
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract Severe reductions of vision and blindness due to ocular disease and trauma are major clinical problems that have serious consequences on the Veteran's quality of life. Optic neuropathies from injury to the retina and optic nerve are characterized by a loss of ganglion cells and their axons. Ganglion cell death is initiated by excessive intracellular Ca2+ levels followed by a cascade of deleterious cellular processes that result in apoptosis. Consistent with this observation is the enhan...

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