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Project Number: | I01BX001669-05A1 |
| Title: | Chromatin Accessibility and Transcription Factor Networks in Rheumatoid Arthritis |
| Principal Investigator: | Jorg J. Goronzy |
| Location: | Palo Alto, CA |
| Congressional District Code: | 14 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2016 - September 2021 |
| FY 2021 Funding Amount: | $80,000 |
| Total Award Amount (all years): |
$747,500 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Rheumatoid arthritis (RA) is a chronic inflammatory disease that manifests predominantly as a destructive synovitis. In spite of the prominence of the synovial inflammation, many immunological abnormalities are systemic. Autoantibodies are not tissue-specific and are directed against global antigens such as Ig Fc determinants and neoantigens of citrullinated peptides. T cell abnormalities in RA are already detectable in naïve T cells. Naïve T cells from RA patients have a lowered signaling thres... |