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Funded Project Details - FY2021

Project Number:

Title: Chromatin Accessibility and Transcription Factor Networks in Rheumatoid Arthritis
Principal Investigator:

Jorg J. Goronzy

Location: Palo Alto, CA
Congressional District Code: 14
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - September 2021
FY 2021 Funding Amount: $80,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Rheumatoid arthritis (RA) is a chronic inflammatory disease that manifests predominantly as a destructive synovitis. In spite of the prominence of the synovial inflammation, many immunological abnormalities are systemic. Autoantibodies are not tissue-specific and are directed against global antigens such as Ig Fc determinants and neoantigens of citrullinated peptides. T cell abnormalities in RA are already detectable in naïve T cells. Naïve T cells from RA patients have a lowered signaling thres...

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