Funded Project Details - FY2021
|Title:|| Chromatin Accessibility and Transcription Factor Networks in Rheumatoid Arthritis|
Jorg J. Goronzy
||Palo Alto, CA
|Congressional District Code:
||Biomedical Laboratory R&D
|| October 2016 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
Rheumatoid arthritis (RA) is a chronic inflammatory disease that manifests predominantly as a destructive synovitis. In spite of the prominence of the synovial inflammation, many immunological abnormalities are systemic. Autoantibodies are not tissue-specific and are directed against global antigens such as Ig Fc determinants and neoantigens of citrullinated peptides. T cell abnormalities in RA are already detectable in naïve T cells. Naïve T cells from RA patients have a lowered signaling thres...
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