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Funded Project Details - FY2021




Project Number:

I01BX000824-05A2
Title: SPROUTY: PUTATIVE ONCOGENE IN COLORECTAL CANCER
Principal Investigator:

Sharad Khare

Location: Columbia, MO
Congressional District Code: 9
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2021
FY 2021 Funding Amount: $207,270
Total Award Amount
(all years):
$1,536,892
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Colorectal cancer (CRC) is the leading cause of cancer-related death in the United States. Cancer death in CRC is mainly due to tumor recurrence and distant metastasis. Sprouty2 (SPRY2), an endogenous suppressor of receptor tyrosine kinase (RTK)/ Mitogen Activated Protein Kinase (MAPK) signaling pathways, acts as a tumor suppressor in breast, prostate, and liver cancer. We discovered oncogenic role of SPRY2 in CRC. The objectives of this application are to assess the requirement and significance...



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