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Project Number: | I01BX000824-05A2 |
| Title: | SPROUTY: PUTATIVE ONCOGENE IN COLORECTAL CANCER |
| Principal Investigator: | Sharad Khare |
| Location: | Columbia, MO |
| Congressional District Code: | 9 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2017 - December 2021 |
| FY 2021 Funding Amount: | $207,270 |
| Total Award Amount (all years): |
$1,536,892 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Colorectal cancer (CRC) is the leading cause of cancer-related death in the United States. Cancer death in CRC is mainly due to tumor recurrence and distant metastasis. Sprouty2 (SPRY2), an endogenous suppressor of receptor tyrosine kinase (RTK)/ Mitogen Activated Protein Kinase (MAPK) signaling pathways, acts as a tumor suppressor in breast, prostate, and liver cancer. We discovered oncogenic role of SPRY2 in CRC. The objectives of this application are to assess the requirement and significance... |