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Funded Project Details - FY2021

Project Number:

Title: Novel Functions for Ras family GTPases
Principal Investigator:

John OBryan

Location: Charleston, SC
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2020
FY 2021 Funding Amount: $90,173
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary: Ras proteins play a central role in many aspects of biology. These monomeric GTPases cycle between an inactivate GDP-bound state and an active GTP-bound state. Mutational activation of Ras occurs in approximately 30% of human tumors with some cancers such as pancreatic cancer having Ras mutations in >90% of tumors. These cancer associated mutations trap Ras in the GTP-bound state, leading to chronic activation of Ras-regulated signaling pathways and oncogenic transformation. Thu...

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