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Funded Project Details - FY2021

Project Number:

Title: Impact of Corticotropin Releasing Factor on Sleep Regulation
Principal Investigator:

Ronald S. Szymusiak

Location: Sepulveda, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - March 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Insomnia and disturbed sleep are common symptoms in mood and anxiety disorders. Depression and PTSD are associated with dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. Brain levels of corticotrophin-releasing factor (CRF), a critical neuropeptide regulator of the HPA axis, are chronically elevated in these disorders. CRF has well characterized wake-promoting/sleep-disruptive effects. Previous work from our laboratory and others has identified GABAergic neurons in the preoptic hypot...

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