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Project Number: | I01BX000893-05A2 |
| Title: | The role of the M1 macrophage response in the progression of chronic kidney disease |
| Principal Investigator: | Steven D. Crowley |
| Location: | Durham, NC |
| Congressional District Code: | 1 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2016 - March 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$679,340 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Macrophages can have profound effects on the progression of chronic kidney disease (CKD) by shaping the innate immune response. For example, pro-inflammatory M1 macrophages secrete tumor necrosis factor- (TNF) and Interleukin-1 (IL-1), both of which can promulgate kidney injury and fibrosis. Through activation of type 1 angiotensin (AT1) receptors in the kidney, the renin angiotensin system (RAS) similarly plays a key role in progressive kidney damage culminating in renal fibrosis. However, in... |