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Funded Project Details - FY2021

Project Number:

Title: The role of the M1 macrophage response in the progression of chronic kidney disease
Principal Investigator:

Steven D. Crowley

Location: Durham, NC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - March 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Macrophages can have profound effects on the progression of chronic kidney disease (CKD) by shaping the innate immune response. For example, pro-inflammatory M1 macrophages secrete tumor necrosis factor- (TNF) and Interleukin-1 (IL-1), both of which can promulgate kidney injury and fibrosis. Through activation of type 1 angiotensin (AT1) receptors in the kidney, the renin angiotensin system (RAS) similarly plays a key role in progressive kidney damage culminating in renal fibrosis. However, in...

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