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Funded Project Details - FY2021




Project Number:

I01BX003262-01A2
Title: Proximal Differentiation Therapy for K-Ras-Induced Lung Adenocarcinoma
Principal Investigator:

Mark Onaitis

Location: San Diego, CA
Congressional District Code: 52
Research Service: Biomedical Laboratory R&D
Project Period: October 2017 - September 2021
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
$645,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

ABSTRACT Individualized therapeutics for K-RAS mutant lung adenocarcinoma are nonexistent. Recently, we have described a unique interaction between activated K-Ras and the Type II cell that explains the unique ability of the Type II cell to proliferate in response to K-Ras activation. The absence of the transcription factor Sox2 allows Notch to be upregulated when K-Ras is activated. In addition, K-Ras is able to induce a transcriptional program that dedifferentiates distal lung epithelial cells...



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