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Funded Project Details - FY2021




Project Number:

I01BX003478-01A1
Title: SNO transport regulates endothelial adhesion of RBCs
Principal Investigator:

Timothy J. McMahon

Location: Durham, NC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - March 2021
FY 2021 Funding Amount: $41,250
Total Award Amount
(all years):
$633,750
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

PROJECT SUMMARY Red blood cell (RBC) transfusion is costly, and is among the procedures most frequently performed in VA and other health care settings. Growing evidence, however, suggests that many anemic patients may not benefit from RBC transfusion, and that blood function declines even during short storage periods. We have identified a novel mechanism whereby RBCs normally export nitric oxide (NO)-derived signals to the vasculature, facilitating the flow of blood itself. S-nitrosothiols (SNOs...



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