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Project Number: | I01BX003478-01A1 |
| Title: | SNO transport regulates endothelial adhesion of RBCs |
| Principal Investigator: | Timothy J. McMahon |
| Location: | Durham, NC |
| Congressional District Code: | 1 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2017 - March 2021 |
| FY 2021 Funding Amount: | $41,250 |
| Total Award Amount (all years): |
$633,750 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: PROJECT SUMMARY Red blood cell (RBC) transfusion is costly, and is among the procedures most frequently performed in VA and other health care settings. Growing evidence, however, suggests that many anemic patients may not benefit from RBC transfusion, and that blood function declines even during short storage periods. We have identified a novel mechanism whereby RBCs normally export nitric oxide (NO)-derived signals to the vasculature, facilitating the flow of blood itself. S-nitrosothiols (SNOs... |