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Project Number: | I01BX003747-01 |
| Title: | Ectopic Lipids in the Pancreatic Alpha Cell Link Insulin Resistance to Hyperglycemia |
| Principal Investigator: | Roger H. Unger |
| Location: | Dallas, TX |
| Congressional District Code: | 30 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2017 - December 2020 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$642,500 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Ectopic Lipids in the Pancreatic Alpha Cells Link Insulin Resistance to Hyperglycemia Just as insulin insufficiency can lead to elevated glucagon secretion, preliminary data suggest that impaired insulin action within the -cell can also promote hyperglucagonemia, hyperglycemia, aberrant gluconeogenesis, and excess glucose efflux from the liver. Pancreatic perfusion with anti-insulin serum causes marked hyperglucagonemia, and ablation of insulin receptor from -cells prompts fed hyperglucagonem... |