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Funded Project Details - FY2021

Project Number:

Title: Dopamine D2 Receptor Splice Variants and Autoreceptor Function
Principal Investigator:

Kim Arthur Neve

Location: Portland, OR
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - March 2021
FY 2021 Funding Amount: $225,456
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The five subtypes of dopamine receptors (D1-D5) are members of the superfamily of G protein-coupled receptors. The D1 and D2 subtypes are the most abundant and mediate most classic dopamine-dependent behaviors. This application is focused on the D2 receptor and, in particular, on the functional significance of a 29-residue fragment in the third cytoplasmic loop that is alternatively spliced to produce the short and long forms of the D2 receptor, D2S and D2L. Considerable evidence indicates that...

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