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Funded Project Details - FY2021




Project Number:

I01BX003315-01A2
Title: Epigenetic Control of Melanoma by MAGE Transcription Factors
Principal Investigator:

Bruce Jack Longley

Location: Madison, WI
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - December 2021
FY 2021 Funding Amount: $78,400
Total Award Amount
(all years):
$699,476
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Melanoma develops as melanocytes accumulate genetic and epigenetic abnormalities, typically causing oncogene activation and senescence, followed by escape from senescence and loss of tumor suppression. Members of the Class I MAGE gene family are normally expressed only in developing germ cells and placenta but their expression is activated in many malignancies including melanoma. Class I MAGE protein expression is associated with poor clinical outcomes and resistance to treatment, and knockdown...



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