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Project Number: | I01BX003315-01A2 |
| Title: | Epigenetic Control of Melanoma by MAGE Transcription Factors |
| Principal Investigator: | Bruce Jack Longley |
| Location: | Madison, WI |
| Congressional District Code: | 2 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2017 - December 2021 |
| FY 2021 Funding Amount: | $78,400 |
| Total Award Amount (all years): |
$699,476 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Melanoma develops as melanocytes accumulate genetic and epigenetic abnormalities, typically causing oncogene activation and senescence, followed by escape from senescence and loss of tumor suppression. Members of the Class I MAGE gene family are normally expressed only in developing germ cells and placenta but their expression is activated in many malignancies including melanoma. Class I MAGE protein expression is associated with poor clinical outcomes and resistance to treatment, and knockdown... |