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Funded Project Details - FY2021

Project Number:

Title: Epigenetic Control of Melanoma by MAGE Transcription Factors
Principal Investigator:

Bruce Jack Longley

Location: Madison, WI
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - December 2021
FY 2021 Funding Amount: $78,400
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Melanoma develops as melanocytes accumulate genetic and epigenetic abnormalities, typically causing oncogene activation and senescence, followed by escape from senescence and loss of tumor suppression. Members of the Class I MAGE gene family are normally expressed only in developing germ cells and placenta but their expression is activated in many malignancies including melanoma. Class I MAGE protein expression is associated with poor clinical outcomes and resistance to treatment, and knockdown...

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