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Funded Project Details - FY2021




Project Number:

I01BX003523-01A1
Title: Epigenetic Mechanism Linking Diabetes and Cognitive Dysfunction
Principal Investigator:

Jun Wang

Location: Bronx, NY
Congressional District Code: 13
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - June 2022
FY 2021 Funding Amount: $242,029
Total Award Amount
(all years):
$1,319,526
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

SUMMARY The overall goal of the proposed studies is to test the hypothesis that type 2 diabetes (T2D)-induced epigenetic changes in the brain may contribute to cognitive decline by altering the expression of mitochondrial and synaptic genes, resulting in cellular energy metabolism dysregulation and neuronal and dendritic spine structure/activity impairments, ultimately leading to cognitive dysfunction. It is known that diabetes is a risk factor for dementia. However, the underlying mechanisms li...



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