Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government
ORD only    All VA Research websites

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021

Project Number:

Title: Epigenetic Mechanism Linking Diabetes and Cognitive Dysfunction
Principal Investigator:

Jun Wang

Location: Bronx, NY
Congressional District Code: 13
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - June 2022
FY 2021 Funding Amount: $242,029
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


SUMMARY The overall goal of the proposed studies is to test the hypothesis that type 2 diabetes (T2D)-induced epigenetic changes in the brain may contribute to cognitive decline by altering the expression of mitochondrial and synaptic genes, resulting in cellular energy metabolism dysregulation and neuronal and dendritic spine structure/activity impairments, ultimately leading to cognitive dysfunction. It is known that diabetes is a risk factor for dementia. However, the underlying mechanisms li...

Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.