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Funded Project Details - FY2021




Project Number:

I01BX003401-01A1
Title: Mechanisms of Neuroprotective Therapy in TBI
Principal Investigator:

Avtar K. Singh

Location: Charleston, SC
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2020
FY 2021 Funding Amount: $41,250
Total Award Amount
(all years):
$683,383
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Traumatic brain injury (TBI) is a neurodegenerative disease in which nitric oxide (NO)-based anti-inflammatory and anti-excitotoxicity mechanisms are derailed, resulting in a disturbed NO metabolome. NO metabolites S- nitrosoglutathione (GSNO) and peroxynitrite (ONOO-) participate in opposing mechanisms (neuroprotection and neurodegeneration, respectively) by regulation of neuronal nitric oxide synthase (nNOS)- and calpain- mediated deleterious mechanisms. A prolonged and sustained increase in n...



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