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Funded Project Details - FY2021

Project Number:

Title: Neuroinflammation and Neurodegeneration in a Transgenic Alzheimer Rat with Vascular Disease
Principal Investigator:

Sally A. Frautschy

Location: Sepulveda, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2020
FY 2021 Funding Amount: $41,250
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Vascular dementia (VaD) is often caused by small vessel arteriosclerotic disease, resulting in ischemic damage to white matter and associated neurodegeneration. Autopsy studies indicate that such changes contribute to the roughly one-third of dementia cases attributed to mixed pathology (MxD), with features of both Alzheimer's disease (AD) and VaD. MxD is particularly prevalent among older Veterans, who have increased risk factors such as metabolic syndrome and cardiovascular disease. However, c...

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