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Funded Project Details - FY2021

Project Number:

Title: Understanding Susceptibility to Parkinson's Disease due to GBA1 Mutations
Principal Investigator:

Marie Y Davis

Location: Seattle, WA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2021
FY 2021 Funding Amount: $335,991
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


PROJECT SUMMARY Parkinson’s disease (PD) is the second most common neurodegenerative disease, and ~60,000 veterans currently receive care for PD from the VA Health Care System annually. PD is characterized by progressive motor decline and cognitive impairment. Despite significant medical burden, our understanding of the pathogenesis of PD and therapies remain limited. Mutations in the gene glucosidase, beta acid 1 (GBA1) are the strongest genetic risk factor for developing idiopathic PD, incre...

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